| Splenectomy |
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| Why Is the Spleen Important In ITP? |
 | The spleen plays an important role in ITP because cells in the spleen called B-lymphocytes produce antibodies that attach to platelets. |
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| These antibody-covered platelets are then removed from the circulation by the spleen. |
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| When Would Splenectomy Be Considered As a Treatment Option for ITP? |
| Splenectomy may be considered for severe or long-lasting cases of ITP that have not responded to other treatment options. |
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| The decision to perform a splenectomy is based on the severity of the ITP and the life style of the individual patient. |
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| Who Is Eligible for Splenectomy? |
| In general, patients older than 5 years of age who have had ITP for more than 1 - 3 years (depending on the individual and the physician) may be candidates for splenectomy. |
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| In severe cases, where the platelet counts remain severely low and do not improve with medication, splenectomy may be recommended soon after the disease is diagnosed. |
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| What Are the Medical Issues Associated with Splenectomy? |
| About 75% of children with severe ITP are cured with splenectomy, but since it is considered major surgery, there is some risk during and after the operation. |
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| Special immunizations (shots) are required before splenectomy. |
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| Following surgery, a child will need to take a daily dose of penicillin, since there is an increased risk of developing a blood infection after splenectomy. |
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| Once the spleen has been removed, patients should notify their physicians immediately if they develop a fever. |
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